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MTHFR Genetic Test
MTHFR Genetic Test
MTHFR Genetic Test

MTHFR Genetic Test

Regular price $197.00 Sale price $149.00

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What if Your Child's ADHD was reversible? 

Test TODAY, learn which MTHFR mutation your child has and get a better understanding of how to treat your child.

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The MTHFR test is a simple, effective and reliable way to test if you have an MTHFR mutation. Follow us at


Differences Between the tests

Test Kit

Tests for MTHFR A1298C and MTHFR C677T. This test explains which specific MTHFR mutation you have, and whether you are heterozygous (1 mutation), homozygous (2 mutations), or compound heterozygous (1 copy of A1298C and 1 copy of C677T).


Tests for both MTHFR A1298C and MTHFR C677T, as well as COMT VAL158MET
If you have both COMT and MTHFR mutations, you are at an increased risk for feeling stressed and anxious. MTHFR mutations create a methylation deficiency. Methylation is essential for many body processes such as healthy neurotransmitter production and breakdown. Methyl groups help the body produce adequate amounts of serotonin, dopamine, and adrenaline. With COMT mutations, you experience slower breakdown speeds of neurotransmitters, and with MTHFR mutations your body is producing fewer neurotransmitters or is unable to properly breakdown neurotransmitters. Having a combination of both of these mutations results in a predisposition to anxiety.


Tests for COMT VAL158MET.
Finding out whether or not a COMT mutation is affecting your neurotransmitter breakdown, can allow you to choose supplementation that will help improve your symptoms. For example, for individuals with COMT mutations, TMG (Betaine) is often the most effective choice in methyl donor. Methylated B vitamins are often over stimulatory when COMT mutations are involved. As well, they are promoters/co-factors for many other pathways which means they can cause a lot of undesirable reactions. Therefore, testing for this mutation can help you understand why your body reacts to certain vitamins in negative ways, and you can choose supplementation and nutrition that is right for your genes


Both MTHFR and COMT genes are involved in the methylation pathway and testing their function is important to better understand your body’s functions such as:

  • Brain chemistry important for mood, anxiety, and stress
  • Immune function
  • Controlling inflammation
  • Energy production
  • Detoxification of chemicals and toxins
  • Cardiovascular health

The COMT (catechol-O-methyltransferase)gene codes for the essential COMT enzyme that is involved in the inactivation of catecholamines such as dopamine, epinephrine, norepinephrine, and catechol estrogens. 1-3 Scientific research has demonstrated that a common mutation in the COMT locus results in the replacement of the amino acid valine with methionine at position 158 in the enzyme. This causes a dramatic reduction in the enzyme’s ability to metabolize these neurotransmitters and catechol estrogens

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Buccal Swab
Our test kit is minimally invasive, NO blood draw needed. Easy to use, a convenient test that can be performed in the privacy of your home. Designed for all ages including infants. Tests for MTHFR A1298C and MTHFR C677T.

Test Kit includes:

  • A Simple Requisition Form
  • Two (2) Sterile Buccal Swabs
  • Instructions
  • Mailing Envelope