MTHFR Maintenance Packages for 1298A & C and C677T Mutations


Biome IQ’s products are focused on helping individuals with MTHFR mutations get the proper methylation and nutrients they need in order to detoxify their bodies and reduce their symptoms. We are the first company to create genetically specific protocols based on MTHFR gene mutations.

 

MTHFR Terminology Basics:

At nucleotide 1298 of the MTHFR, there are two possibilities: A or C. 1298A (leading to a Glu at amino acid 429) is the most common while 1298C (leading to an Ala substitution at amino acid 429) is less common. 1298AA is the “normal” homozygous, 1298AC the heterozygous, and 1298CC the homozygous for the “variant”.  (for more information click here..)

 

C677T or rs1801133 is a genetic variation—a single nucleotide polymorphism (SNP)—in the MTHFR gene.
You get one copy of this gene from your mother and one from your father, so there are two possible copies that can be either “normal” or “mutant”. (For more information click here..)

 

  • MTHFR C677C = normal MTHFR gene
  • MTHFR C677T = heterozygous mutation (one mutation)
  • MTHFR T677T = homozygous mutation (two mutations)
  • MTHFR A1298A = normal MTHFR gene
  • MTHFR A1298C = heterozygous mutation (one mutation)
  • MTHFR C1298C = homozygous mutation (two mutations)
  • MTHFR C677T + MTHFR A1298C = a compound heterozygous mutation

Individuals with two copies of 677C (677CC) have the most common genotype. 677TT individuals (homozygous) have lower MTHFR activity than CC or CT (heterozygous) individuals